I'm going to have to say the shotgun on Halo I and I choose this because this gun helped to lead me to many glorious victories!

Has to be the mini-gun from Predator. Best gun to ever hit the big screen, most new ones have been rip-offs.

I would have to go with the Wave Motion Gun from Star Blazers (Space Battleship Yamato). I used to love that show when I was a kid and have yet to see anything like it (other than the Death Star). Second would have to be the Noisy Cricket from MIB.

Noisy Cricket gets my vote.

Megatron IS a gun. Ho much more bada$$ can you get?

Vera, from Firefly. Not a prominent weapon... but it certain made the "Mrs. Reynolds" episode that much more enjoyable.

Awww, man... Somebody already mentioned Vera. "it is my very favorite gun."

"See, Vera? Dress yourself up, you get taken out somewhere fun.!"

I have to say, I like Mal's custom octagonal barrel sidearm. Much more intimidating than Jubil Early's little toy, no matter how finely it was crafted. Yet Mal's gun is very much a worn-in, trusted partner of a weapon.

"Well, my days of not taking you seriously are certainly comin' to a middle."

The ZF-1 from the Fifth Element puts all those guns to shame!

If it is ok to quote from anime, the cross machinegun from Trigun!

I now its not a movie, but Ronan's gun from SGA...

Mad Max's Double Barreled sawed off
Terminator 2 Mini Gatlin gun or MM1 grenade launcher
Barbarella's rifle
The Death Star

BOBADIAH great choice! The Wave motion gun could wipe out whole galaxies, those were the days :)
But in terms of one carried around by someone, how about the Rock's in DOOM? "BIG GUN!"

Wait wait wait... You want to know the best gun ever? Mega-man X's hand blaster! Its a part of his arm for peats sake!

I liked the gun the guys in The Hitchikers Guide to The Galaxy went off to get.
You know, the one that made men understand feelings.. ;-)
Horrbile thing in Marvins hands..

It's a little obvious, but my favorite will always be Han Solo's Blaster. I would say it is one of the best props ever made, its sound was perfect, and what other gun was weilded in a more badazz way... Took down Greedo, Stormtroopers, and even took a few pot shots at Vader... What other gun could make those claims...

the best seems to have been forgotten
how about the lawgiver from Judge Dredd. nifty little sidearm to have around with functions like fully automatic, flare, grenade and of course double whammy. than don't forget that it cannot be handled by anyone with a different DNA than yourself and it leaves a genetic flag for who ever fired it on each bullet.

The Ixian "Weapom" from ChapterHouse: Dune.

Stand in front of a million man army, and watch them fall as the life simply leaves their bodies. Single shot, unfortunately.

pulse rifle, aliens. i still have dreams about that damn thing...

I'm gonna go with the Samaritan from Hellboy. It's not particularly special, but I love the way he introduces it in the first movie. "I'm not a good shot, but the Samaritan here shoots really big bullets."

I think a real close second would go to the pulse blaster thing from Minority Report.

since we are including cartoons and anime, my number one would have to be the caster gun from outlaw star

+1 on megatron. he's a gun.

or not a movie anyway, but from a photo-novel - the BFG that the FA-010-A FAZZ carries.

My vote goes to the Sandman's gun from Logan's Run. It shoots flames and looks cool as hell.

I vote for "The Rail Gun" that shoots projectiles at near light speed from the Movie 'The Eraser'.